| Esvan-Jesús Pérez-Pérez | Tecnológico Nacional de México |
| Guillermo Valencia-Palomo | Tecnológico Nacional de México |
| Vicenc Puig | Universitat Politecnica de Catalunya |
| Ildeberto Santos-Ruiz | Tecnológico Nacional de México |
| Julio-Alberto Guzmán-Rabasa | Universidad Politécnica de Chiapas |
https://doi.org/10.58571/CNCA.AMCA.2025.001
Resumen: This work presents a hybrid fault diagnosis framework for Continuous Stirred Tank Reactor (CSTR) bioreactors by integrating Adaptive Neuro-Fuzzy Inference Systems (ANFIS) and Zonotopic Kalman Filters (ZKF). The proposed method consists of two main stages: (1) modeling the nominal behavior of the CSTR using ANFIS trained on fault-free data to extract a compact set of fuzzy rules, and (2) implementing a ZKF to estimate system states and detect deviations associated with faults. The neuro-fuzzy model captures the system’s dynamics, while the zonotopic filter accounts for bounded uncertainty and measurement noise. Fault detection is achieved by evaluating residuals and comparing them to adaptive thresholds derived from the zonotopic bounds. Simulation results for different actuator and sensor fault scenarios
demonstrate the effectiveness of the proposed approach in identifying deviations from normal operation, highlighting its potential for improving monitoring capabilities in bioprocesses.

¿Cómo citar?
Pérez-Pérez, E., Valencia-Palomo, G., Puig, V., Santos-Ruiz, I. & Guzmán-Rabasa, J. (2025). Fault Diagnosis Framework for a CSTR Bioreactor Integrating ANFIS and Zonotopic Estimation. Memorias del Congreso Nacional de Control Automático 2025, pp. 1-6. https://doi.org/10.58571/CNCA.AMCA.2025.001
Palabras clave
Fault diagnosis, CSTR, ANFIS, Zonotopic Kalman Filter, Bioprocess.
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