A Robust Interval Predictor–based Controller for Anesthesia Machines Using Propofol and Remifentanil

https://doi.org/10.58571/CNCA.AMCA.2025.043

Resumen: This paper tackles the Bispectral Index (BIS) regulation problem in automated anesthetic procedures using propofol and remifentanil simultaneously. The controller design is based on an interval predictor that does not require any filtering or observer design to estimate the drug concentrations on the patient’s effect–site, and only the direct measurement of the BIS signal and the knowledge of a feasible interval of initial condition are needed. The design takes into account the pharmacodynamic and pharmacokinetic models and ensures the convergence of the regulation error to a compact set around the origin despite perturbations.

¿Cómo citar?

Mera, M., Ramírez–Barrios, M., Avilés, J. & Ríos, H. (2025). A Robust Interval Predictor–based Controller for Anesthesia Machines Using Propofol and Remifentanil. Memorias del Congreso Nacional de Control Automático 2025, pp. 250-255. https://doi.org/10.58571/CNCA.AMCA.2025.043

Palabras clave

Interval Predictor, Anesthesia, Positive Systems.

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